The incidence of abnormal renal function (based on a creatinine clearance < 60 mL/min/1.73 m2), abnormal liver function (based on AST or ALT twice the upper limit of the ‘normal’ value), and hematological disturbances reflected by lymphopenia (defined as lymphocytes < 1 × 109/L) were higher in the high inflammatory endotype (p value =  < 0.001, 0.020, < 0.001, respectively), whereas there was no difference in leukocytosis (defined as leukocytes > 10 × 109/L; p value = 0.273). This evidence concerns the gene GPT and Increased total leukocyte count.