CD4 and mitochondrial DNA depletion syndrome 4a: In this study, we calculatedvariation in CD4 cell counts from the first ANC visit, on what he median (IQR)gestational age at ANC enrolment was 21 [15–25] weeks, therefore, after thefirst trimester of pregnancy.In 12.5% of the HIV-infected women with AHD at the sixmonth visit and in 14.2% of the HIV-infected women without AHD at the 12 monthvisit after the first ANC, a “less thanexpected improvement in CD4+ cellcounts” was observed, with a reduction in the CD4+cell count of 274.5 cells/mm3 and of 117.7 cells/mm3, respectively.