For the HK-2 cell line, the IFNL related genes were not up-regulated after ZIKV infection (Fig. 1d), but the innate immune response was significantly induced, including ZBP1, which plays a role in the innate immune response by binding to foreign DNA and inducing type-I interferon production [36], as well as OAS2, an essential protein involved in the innate immune response to viral infection [37]. This evidence concerns the gene ZBP1 and viral infectious disease.