TNFRSF14 and Zika virus infectious disease: CCL5 and TNFSF14 were associated with T-cell mediated cell immunity, with the former encoded one of the major HIV-suppressive factors produced by CD8 + T-cells [23], whose upregulation induced human placental damage and excessive inflammation after ZIKV infection [24, 25], while the latter encoded a ligand for TNFRSF14/HVEM, co-stimulating T cell proliferation [26].