IFNA1 and Zika virus infectious disease: This study reveals the biological response and pathways against ZIKV infection in different human organs or tissues, such as GnRH signaling pathway in placental choriocarcinoma JEG-3 cells, MAPK signaling pathway in astrocytes U 251-MG cells, PPAR signaling pathway in renal-derived HK-2 cell lines and IFN-related pathway activation in all three cell lines.