Compared with Asian strain, the experimental infection of human-induced neuroprogenitor stem cells (hiNPCs) with American ZIKV resulted in a diminished induction of IFNs stimulated genes (ISGs) and lower induction of several cytokines including IFN-α, IL-1α/β, IL-6, IL-8, and IL-15, which consequently favoring virus replication [84]. Here, IL1A is linked to infection.