For example, ZIKV infection induced the RIG-I-like receptor (retinoic acid-inducible gene I-like receptors, RLR) signaling pathway in the JEG-3 cell line (Fig. 3a, Supplementary Table 14), where RIG-I could detect viral RNAs and activate the type I IFN-mediated antiviral immune response during infection [43]. This evidence concerns the gene RIGI and Zika virus infectious disease.