Analysis of antiviral gene expression shows that type I interferon (IFN) signaling pathway, including RIG-I-like receptor (RLR) transcription as well as downstream antiviral effector genes, was up-regulated in HCs after ZIKV infection (24 and 48 h post-infection, the late time point) [19]. The gene discussed is IFNA1; the disease is Zika virus infectious disease.