Differently, ZIKV infection tended to up-regulate IFNL3 with FC value of 351-fold in the JEG-3 cell line (Fig. 1b) but up-regulated IFNL1 with FC value of 102.6-fold in U-251 MG cells (Fig. 1c), indicating IFNL3 in the placenta may be more sensitive for antiviral effects. This evidence concerns the gene IFNL1 and Zika virus infectious disease.