Phosducin-like 2 (PDCL2) is encoded by the phosducin-II subgroup (PhLP2) of the phosducin (Pdc) gene family.1 It has been found that PDCL2 forms a complex with heat shock protein Hsp90,2 functions as chaperone, and is essential for cell growth in unicellular organisms.3,4,5 More importantly, PDCL2 is a testis-specific phosphoprotein in mice and humans.6,7 Previously, we discovered that CRISPR/Cas9-mediated PDCL2 mutant male mice are sterile due to globozoospermia caused by impaired sperm head formation (accompanying paper submitted to Andrology). The gene discussed is PDC; the disease is Globozoospermia.