TF and cancer: A trichotomous analysis for each cancer type separating TF into TF <1%, 1%, ≤TF < 10%, and ≥10% showed a stepwise prognostic difference suggestive of a dose-dependent effect for mCRPC and aNSCLC, but less so for mBC and mCRC (Supplementary Figure S5, available at https://doi.org/10.1016/j.annonc.2022.09.163).