While recent prospective trials employed choline PET/CT, a growing body of evidence suggests that staging with PSMA-PET/CT is associated with better survival in omPCa management compared to other tracers.30, 31, 32, 33, 34, 35 PSMA is a transmembrane protein that is highly overexpressed on the cell membrane of nearly all prostatic cancer cells and may also correlate with advanced disease stages and castration-resistant prostate cancer (CRPC).36 This evidence concerns the gene FOLH1 and prostate cancer.