After adjusting for demographics (sex, age, and BMI), clinical risk factors (smoking, hypertension, diabetes, CHD, previous IS, and history of oral antiplatelet and anticoagulant medications), and CHA2DS2‐VASc scores, we found that NT‐proBNP, d‐dimer, and LAD were independent risk factors for IS in patients with NVAF (odds ratio [OR] = 1.12, 95% confidence interval [CI]:1.08–1.16; OR = 1.87, 95% CI: 1.37–2.55; OR = 1.21, 95% CI: 1.13–1.28, p < .01). This evidence concerns the gene NPPB and Hypertension.