Liu et al. reported that expression of several important regulators of endoplasmic reticulum stress such as activating transcription factor 4 (ATF4), activating transcription factor 6 (ATF6), X box‐binding protein 1 (XBP‐1)and C/EBP‐homologous protein (CHOP)was increased, followed by G‐1 treatment in colon cancer (HCT116) cells.28 Here, ATF4 is linked to malignant colon neoplasm.