Besides, ERβ could inhibit the mammalian target of rapamycin (mTOR) or activate Bcl‐2/adenovirus E1B 19‐kDa‐interacting protein 3 (BNIP3) to promote autophagy in colon cancer (HCT116) cells.27 The gene discussed is ESR2; the disease is malignant colon neoplasm.