Inhibits cell migration by decreasing the expression of urokinase plasminogen activator (u‐PA), tissue‐type plasminogen activator (t‐PA) and matrix metalloproteinase 9 (MMP‐9) as well as matrix metalloproteinase 2/9 (MMP‐2/9) activity in colon cancer cells. The gene discussed is PLAU; the disease is colonic neoplasm.