FOXO3 and neoplasm: Tsuji et al. report that FOXO3 is a potential tumor suppressor for FOXO3 cytoplasmic distributed (FOXO3-Cyt) GC cells, while PI3K/AKT pathway activation protects FOXO3-Cyt GC cells from FOXO3-mediated growth suppression by the FOXO3 nuclear export [101].