It has been reported [46, 47] that during evolution, women tend to store fat in subcutaneous adipose tissue in order to cope with the risk of nutritional deficiencies during lactation, while men tend to store fat more in visceral adipose tissue, and the accumulation of visceral fat would reduce serum adiponectin, which may increase the risk of NAFLD. Here, ADIPOQ is linked to metabolic dysfunction-associated steatotic liver disease.