The Cancer Genome Atlas (TCGA) database analysis (GEPIA) tool (http://gepia.cancer-pku.cn/) revealed that the level of ARHGAP25 was significantly lower in NSCLC (including 486 squamous lung carcinomas and 483 lung adenocarcinomas) tissues than in normal tissues (P < 0.001; Fig. 5A). The gene discussed is ARHGAP25; the disease is non-small cell lung carcinoma.