The fluid shear stress and atherosclerosis pathway shares various processes with the PI3k-AKT signaling, focal adhesion, NF-κB signaling, MAPK signaling pathways, which are key regulation pathways in osteoblast proliferation [27, 28, 49, 50, 52, 53, 70–72]. The gene discussed is PIK3CG; the disease is atherosclerosis.