CD4+ T cell stimulation with Nt-INSP-4, oxPTM-INSP-6 and oxPTM-INSP-3 was associated with antibody reactivity to oxPTM-INS in 8/18 (44.4%), 8/18 (44.4%) and 7/18 (38.9%) participants with type 1 diabetes. The gene discussed is CD4; the disease is type 1 diabetes mellitus.