CD4 and type 1 diabetes mellitus: When comparing response to oxPTM-INSPs and Nt-INSPs among type 1 diabetes patients, we found that CD4+ response to oxPTM-INSP-6 was more frequent compared with Nt-INSP-6 (66.7% vs 27.8%; p=0.045) (Fig. 4a,b, ESM Table 4).