SARM1 and amyotrophic lateral sclerosis: Finally, the recent finding that zika virus causes SARM1-dependent neuronal death [9], along with earlier indications of similar effects with both rabies and West Nile virus [10, 11], albeit so far by unknown mechanisms, raise the important question of whether endemic viruses could make an as-yet unrecognised contribution to neurodegenerative disorders such as ALS by acting on SARM1.