For example, C9orf72-derived arginine-containing dipeptide repeats, which are associated with its ALS mutation and remain a good candidate for the pathogenic mechanism, disrupt axonal transport [44], while TDP-43 also has a role in regulating axonal protein synthesis [45] and it pathogenic variants also disrupt axonal transport of signalling endosomes [46]. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.