Additionally, lncRNA EGFR has a positive feedback loop in Treg, where it increases the expression of EGFR resulting in activation of the expression of its downstream extracellular signal-regulated kinases 1/2 (ERK1/2), Activator protein 1 (AP-1) and Foxp3 expression, which induce immunosuppression in HCC patients [35]. Here, MAPK3 is linked to hepatocellular carcinoma.