MAPK1 and hepatocellular carcinoma: Another study showed that crosslinking between lncRNA H19 and TAMs in EMT induced stemness and accelerated HCC invasion of HCC cells in vitro through modulation and activation of the miR-193b/MAPK1 axis, suggesting that lncRNA H19 could be a promising anti-cancer therapy strategy for reducing HCC aggression and improving clinical outcomes [51].