For Example, in breast cancer, overexpression of lncRNA small nucleolar RNA host gene 1 (SNHG1) could decrease immune escape and tumor progression by enhancing the expression of miRNA- 448 and repression of Indoleamine 2,3-dioxygenase (IDO) level, resulting in inhibition of Treg differentiation. The gene discussed is SNHG1; the disease is neoplasm.