Tumor cells B16, CT26, U-2 OS and SGC-7901 that expressing 2–5 subtypes of sstrs, were more sensitive to vaccinia VG9/(SST-14)2-HSA than VG9/TK− at high MOI, which proved that vaccinia virus and (SST-14)2-HSA possess a combined oncolytic effect. The gene discussed is ALB; the disease is neoplasm.