MMP1 and colorectal cancer: The results from Western blot analysis showed that SP600125 treatment suppressed the expression of p–c-Jun (Ser73), c-Jun and MMP-1 in both tested colorectal cancer cells (Fig. 6B); interestingly, the increase expression of p–c-Jun (Ser73), c-Jun and MMP-1 induced by CAMSAP2 was also attenuated in response to SP600125 treatment (Fig. 6B).