JUN and colorectal cancer: Moreover, inhibition of JNK/c-Jun signaling by a specific chemical inhibitor (SP600125) downregulated the transcription activity of MMP-1 and inhibited the capabilities of migration and invasion mediated by CAMSAP2 in colorectal cancer cells, indicating JNK/c-Jun signaling is essential for CAMSAP2-induced metastasis in colorectal cancer.