FURIN and cancer: Increasing statistical power through a gene-based GWAS of the gSEM summary statistics identified two novel GWS genes for OA: PPP6C and FURIN. PPP6C (Protein Phosphatase 6 Catalytic subunit gene) is a component of a signaling pathway that regulates cell cycle progression known to be involved with the immune system and cancer (https://www.uniprot.org/uniprot/O00743#function).