The crucial role of IKCs is further underscored by the fact that mutations in the KCNB1 gene are found in children affected by developmental and epileptic encephalopathies (DEEs), neurological conditions characterized by severe developmental delays, that often co-exist with seizures and abundant epileptiform abnormalities [4, 5]. The gene discussed is KCNB1; the disease is developmental and epileptic encephalopathy.