Our hypothesis was that increasing of M1 macrophages, which produce proinflammatory cytokines in the TME, will reflect in increased PIGR expression in breast cancer cells which may be a surrogate biomarker of a favorable outcome in patients with breast cancer. The aim of this study was to determine the role of macrophages and cytokines affecting expression of PIGR in two breast cancer cell lines. The gene discussed is PIGR; the disease is breast carcinoma.