COMP and exfoliation syndrome: Collagen fibril organization was over-represented with three overlapping constituent genes: Col5a1 encodes an alpha chain of type V collagen and the gene family forms a major component of the basement membrane of the corneal endothelium and related genes were altered in the mouse retina after spaceflight11, lysyl-oxidase like Loxl1 has been implicated in pseudoexfoliation syndrome which is a major cause of glaucoma and cardiovascular complications42, and Comp plays a role in vascular wall remodeling43.