Further, to exclude any influence of mutations outside the spike genes of the Delta and the Omicron-BA.1 VOC on replication, immune evasion, or pathogenicity, we used the isogenic viruses SARS-CoV-2S-Delta and SARS-CoV-2S-Omicron that differ only in their spike gene for infection of vaccinated and naïve mice. Here, CHMP5 is linked to infection.