CGAS and cancer: The functional genomics of cancer, as we have defined it here, rests either on (1) the complex combinatorial effects of coding mutations in relevant genes that alter cancer phenotypes, (2) the transcriptional cassettes that generate alterations in critical pathways, (3) whole genome mutational signatures that serve as forensic tools to ascertain the origins of a cancer, or (4) whole genome disruption that activate an immune response either by enhancing the neoantigenic load, or activating the cGAS/STING pathway.