For the M2 phenotype, exposure to periodontitis saliva increased IL-10 and reduced BMP-2 secretion, but had no effect on the TGF-β level; treatment with G3@SeHANs and PAMAM-G3 further increased the IL-10 level and also increased TGF-β and BMP-2 levels. Here, TGFB1 is linked to periodontitis.