TLR9 and periodontitis: We found that cfDNA from periodontitis saliva but not serum, mtDNA but not gDNA, and CpG DNA induced TLR9 activation, and consistently G3@SeHANs reduced all these TLR9 activations, while the soluble PAMAM-G3 only reduced the activation by mtDNA and CpG DNA (Fig. 3f).