Among the 21 genes that have not previously been identified as significantly mutated in cervical cancer, six are SMGs in other SCCs, including head and neck (NOTCH1, JUB (also known as AJUBA), MLL2 (also known as KMT2D), RB1, PIK3R1)20, oesophageal (MLL2, NOTCH1, RB1)21 and lung SCC (NOTCH1, RB1, MLL2, CREBBP (also known as KAT3A))22. The gene discussed is PIK3R1; the disease is cervical cancer.