EP300 and neoplasm: Comparing somatic mutation rates in SMGs between clusters using binomial regression identified PIK3CA (FDR = 0.001) and EP300 (FDR = 0.046) mutations as disproportionally more common in C1 tumours and STK11 (FDR = 0.005) and NF2 (FDR = 0.045) as enriched in C2 tumours (Fig. 4).