Among the 21 genes that have not previously been identified as significantly mutated in cervical cancer, six are SMGs in other SCCs, including head and neck (NOTCH1, JUB (also known as AJUBA), MLL2 (also known as KMT2D), RB1, PIK3R1)20, oesophageal (MLL2, NOTCH1, RB1)21 and lung SCC (NOTCH1, RB1, MLL2, CREBBP (also known as KAT3A))22. Here, NOTCH1 is linked to cervical carcinoma.