Notably, at the KMT2E/SRPK2 locus, the AMD-associated lead variant rs1142 is in contact with the TSS of KMT2E and SRPK2 and with the gene body of 7 genes, which include KMT2E, SRPK2, EFCAB10, LINC01004, PUS7, AC007384.1 and AC005070.3 through 9 chromatin loops (Fig. 7B, top panel). The gene discussed is KMT2E; the disease is age-related macular degeneration.