Moreover, overexpression of ZIP1 in prostate cancer-associated fibroblasts (PCCAFs) and mouse embryonic fibroblasts (MEFs) increased the expression of CX43 (Fig. 2e, Supplementary Fig. 2d, e), implying that the regulation of CX43 by ZIP1 is independent of fibroblast origin. The gene discussed is GJA1; the disease is prostate cancer.