To determine the functional significance of ZNF148 in breast cancer, we used lentivirus to stably express ectopic ZNF148 cDNA into ER+ breast cancer (MCF7), TNBC (MDA-MB-231, BT549, and HCC1806), and normal-like breast (MCF10A) cell lines. This evidence concerns the gene ZNF148 and breast carcinoma.