Some of the high scoring BioChIP-seq enrichment sites included genes that have been implicated in cancer metastases (DDR1 [51], BMP4 [52], and SMAD6 [53]), and cell cycle and survival (CDIP1 [54] and PPP2R5A [55]) (Fig. 4C–E and Supplemental Fig. 5). This evidence concerns the gene SMAD6 and cancer.