To test whether PGRN deficiency’s impact on the brain lipidome was also present in patients with GRN-related FTD, we analyzed the lipid composition of postmortem human frontal and occipital lobe brain tissue from control (n = 3), sporadic FTD (sporadic FTD-TDP, Type A, (n = 6), and GRN mutation-related FTD (GRN FTD-TDP, Type A, (n = 12) subjects (The number of available healthy control samples was unfortunately limited and therefore a limitation of these analyses). This evidence concerns the gene GRN and frontotemporal dementia.