As reported for PGRN-deficient fibroblasts and murine brain6, we found increased levels of SEs and TAGs in the frontal lobes of GRN FTD-TDP subjects; in contrast, TAGs were unchanged, and SEs were below the detection limit in the occipital lobes of the same subjects (Supplementary Fig. 1c and Supplementary Data 2). The gene discussed is GRN; the disease is frontotemporal dementia.