GPT and hepatitis A virus infection: ALT ≥3× ULN and total bilirubin ≥2× ULN.ALT ≥5× ULN.ALT ≥3× ULN if associated with symptoms (new or worsening) believed to be related to hepatitis (such as fatigue, nausea, vomiting, right upper quadrant pain or tenderness or jaundice) or hypersensitivity (such as fever, rash or eosinophilia).Isolated ALT ≥3× ULN that persists for ≥4 weeks.