There was an increased percentage of large nucleoids (>0.45) and medium nucleoids (0.2–0.45) in NDUFA4−/− iPSCs versus WT iPSCs, non-risk (T/T; T/T) versus risk allele (G/G; C/C) iPSCs, and NDUFA4Δ iPSCs versus WT_Δ iPSCs, which is consistent with increased mitochondrial stress in NDUFA4−/− iPSCs, non-risk (T/T; T/T) iPSCs, and NDUFA4Δ iPSCs under both mock and infection conditions (Mock and ZIKVPR infection: Figures 6E and 6F; DENV and ZIKVU infection: Figure S6C). Here, COXFA4 is linked to infection.