To determine how NDUFA4 might impact viral infection, RNA-sequencing was used to compare the global gene expression profiles in WT and NDUFA4−/− iPSCs, iPSCs carrying non-risk (T/T; T/T) and risk (G/G; C/C) alleles, and WT_Δ and NDUFA4Δ iPSCs. This evidence concerns the gene COXFA4 and viral infectious disease.