COXFA4 and Zika virus infectious disease: To avoid the impact of other genetic factors on virus infection, we created isogenic iPSC pairs to study the precise role of NDUFA4, SNPs (rs917172 and rs12386620), and a cis-regulatory region in ZIKV infection, including NDUFA4−/− iPSCs versus WT iPSCs, iPSC lines carrying non-risk (T/T; T/T) versus risk (G/G; C/C) alleles, and NDUFA4Δ iPSCs versus WT_Δ iPSCs.