HIF1A and COVID-19: Compared to healthy controls, early and late deceased COVID-19 patients showed a spatial heterogeneity of angiopoietin 2 (ANPGT1), hypoxia inducible factor 1 alpha (HIF1α), and transforming growth factor beta (TGF-β) as markers of microischemia in immunohistochemistry of affected lung tissue samples (Figure 3g).