Importantly, the combination of IL-12 with suicide genetherapy, such as HSVtk/GCV and CD/5’-FU seems to enhance the antitumor effect inpre-clinical and clinical studies in comparison to suicide gene therapy or IL-12alone, increasing the presence of IL-12, IFNγ, in serum and tumor and inducing aspecific antitumor immune response by NK cells and cytotoxic T cells activationin mouse model and in a phase I clinical trial (Freytag et al., 2013; Barton et al.,2021). Here, IFNG is linked to neoplasm.