Downstream targets of P53 have been investigated as well, including adenoviralvectors expressing P53 upregulated modulator of apoptosis (PUMA) and NADPHoxidase activator (NOXA), other two members of the BCL-2 family that participatein P53-mediated apoptosis (Agrawal et al.,2006; Elmore, 2007), indifferent tumor types (Table S3). Here, TP53 is linked to neoplasm.