In colon cancer, the samestrategy, Ad-P53 containing RGD and P53-responsive promoter, was only effectivein P53 WT or null cell lines and in a mutant TP53 tumor cell,the combination with IFNβ was necessary to induce cell death (Del Valle et al., 2021). The gene discussed is TP53; the disease is malignant colon neoplasm.