TP53 and neoplasm: Adenovirusexpressing P53 under control of a P53-responsive promoter demonstrated effectivetumor suppression (Tamura etal., 2016), which is potentialized when thearginine-glycine-aspartic acid (RGD) motif is incorporated in the adenoviralfiber protein, leading to a higher tumor cell death effect (Tamura et al., 2017) andhigher chemotherapy sensitivity (Tamuraet al., 2020).