The combination of IL-12 oncolytic adenovirus in CIKcells in liver cancer generated higher cytotoxic effect than each separatedtreatment (Yang et al., 2012) andcombination with a TGFβ inhibitor in melanoma cells promoted increased antitumorimmune response as well, leading to CD4+, CD8+ T and NK cells activation andIFNγ secretion in the tumor site (Jiang et al.,2017). Here, CD4 is linked to neoplasm.