Combinatorytreatment using cytokines and RAS-targeted therapy resulted insynergistic tumor inhibition, as seen in pancreatic cancer usingInterferon-alpha (IFN-α) (Hatanaka et al.,2004) and in colon cancer, with Interleukin-27 (IL-27) (Lebedeva et al., 2007). Here, IL27 is linked to malignant colon neoplasm.