To note, the abundance of the TUBB3+ TAMs (TUBB3+ CD68+/CD68+ ratio > 30%) was significantly associated with poorer survival of older NSCLC patients (age > 60; n = 94; P < 0.033, log-rank test; Fig. 2F) and their up-regulated DEGs were highly associated with neural diseases (Huntington’s disease, Parkinson’s disease, and Alzheimer’s disease; red, Fig. 2G and file S2), suggesting a potential contribution of this previously unidentified TAM subset to neurogenesis. The gene discussed is TUBB3; the disease is early-onset autosomal dominant Alzheimer disease.