Intriguingly, we detected calcium flux of the BMDM-derived MNTs (Tubb3+ tdTomato+ cells) in response to the classic nociceptive stimulus capsaicin [an agonist of TRPV proteins that respond to cancer pain sensation (41)], whereas no response was detected in the unstimulated BMDM in vitro (Fig. 4, E and F; movie S2; and fig. Here, TUBB3 is linked to cancer.