We have successfully dissected the dynamics of macrophages under conditions of tissue inflammation and cancer by scRNA-seq (23–25) and unexpectedly uncovered a strong association of the transforming growth factor–β1 (TGF-β1)/Smad3–dependent transcriptomes of bone marrow–derived macrophages (BMDMs) with cancer and neuronal development (differentiation, generation, and morphogenesis) (24). The gene discussed is SMAD3; the disease is cancer.