The results showed that, compared with crude antigens, both TER ATPase and TPx-1 showed a better performance in the diagnosis of human echinococcosis with an AUC of 0.976 (95% CI: 0.960–0.993) and 0.936 (95% CI: 0.898–0.963) (p < 0.01), respectively. The gene discussed is PRDX2; the disease is echinococcosis.