Some studies have reported that Inc-49a is a positive regulator of CD49a in human decidual NK cells [48] and that γδT cells promote the activation of CD49a+ NK cells and upregulate their surface cytotoxic effector molecules (e.g., perforin) through CD137/CD137 L signaling in liver fibrosis [49]. Here, PRF1 is linked to Hepatic fibrosis.