SHISA4 and asthma: Other genes commonly downregulated in severe asthma and PTSD were Protein Tyrosine Phosphatase 4A3 (PTP4A3), known for its role in stimulating progression from G1 to S phase in mitosis [67]; Shisa Family Member 4 (SHISA4), a transmembrane scaffold/adaptor protein [68]; and Tubulin Polymerization Promoting Protein Family Member 3 (TPPP3), a regulator of microtubule dynamics [69].