Commonly downregulated to PTSD and severe asthma were ORMDL3 (2.2E-2, 1.9E-3, 2.7E-3, 3.9E-3), PTP4A3 (2.6E-3, 2.3E-2, 4.5E-3, 5.2E-3), SHISA4 (1.1E-2, 4.4E-2, 9.8E-3, 6.2E-3), and TPPP3 (2.2E-2, 1.1E-2, 3.1E-3, 2.7E-2). The gene discussed is ORMDL3; the disease is post-traumatic stress disorder.