THRIL (TNF- α and hnRNPL immunoregulatory lncRNA) is involved in innate immunity through the regulation of TNF -α expression level by forming a complex that bind TNF- α gene promotor region resulting in its induction, TNF- α is one of the cytokines that collaborate in the inflammatory process and its dysregulation characterizes autoimmune diseases [34]. The gene discussed is HNRNPL; the disease is autoimmune disease.