Moreover, in concordance with the aforementioned gastrocnemius muscle mass results, gastrocnemius muscle gene expression levels of protein degradation pathways including muscle RING finger 1 (MuRF1), muscle atrophy F-box protein (MafBx), ubiquitin, and E214KDa were notably increased in CLD rats compared with normal rats (indicated as a broken line in the graphs), and MafBx mRNA levels were significantly decreased in gastrocnemius muscle from CLD+BCAA rats (p=0.036; Figure 3C). Here, TRIM63 is linked to congenital secretory chloride diarrhea 1.