CRKL and coronary artery disorder: DGCR8 occurred in the 22q11.2 microdeletion region, in the same TOF patient with TBX1- and CRKL-encompassing deletions (Figure 2C), while CYFIP1 occurs in the 15q11.2 locus that has been putatively associated with various types of CHD (Figure 3A).15 In contrast, the dosage sensitivity of the other three genes has not been established or associated with CHD in humans (Figure 3B through 3D), and no patients with CHD or other disorders were found to harbor similar CNVs in DECIPHER.