TBX1 and Abnormal cardiac septum morphology: These included deletion of the 8p23.1 region encompassing the GATA4 gene in a proband with atrial septal defect (ASD), pulmonary stenosis, and ECAs (Figure 2A); deletion of the 11q12.3 region encompassing the B3GAT3 gene in a proband with partial anomalous pulmonary venous connection and ECAs (Figure 2B); and two deletions of the 22q11.2 region encompassing TBX1 and CRKL in a proband with TOF who was previously unrecognized to have 22q11.2 deletion syndrome (Figure 2C).