Although a moderately low estimated glomerular filtration rate (eGFR) level (53 mL/min/1.73 m2) and a high brain natriuretic hormone (BNP) one (508 pg/mL) were found at the baseline, no data suggesting progression of the renal disorder and heart failure were observed during ERT (Fig. 1e, f, green line). Here, NPPB is linked to heart failure.