Interestingly, Kdm5a, Mapk4k, Tgfb1, Rictor, Ppargc1a, Insr, and Rb1, which were among the top upstream regulators which might be involved the dilative phenotype of iCMp38αKO hearts were also found with comparable Z-scores in a proteomic analysis of human heart biopsies from patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) and dilative cardiomyopathy (DCM) [9]. Here, INSR is linked to familial dilated cardiomyopathy.