The analysis of data revealed that the expression of AACS (p = 7.850E-34), ACSF2 (p = 1.900E-10), and AASDH (p = 0.001596) in dataset of HCCDB4 and the expression of AACS (p = 5.510E-26), ACSF2 (p = 5.920E-14), and AASDH (p = 1.410E-11) in dataset of HCCDB18 in HCC tissues were both upregulated, separately (Table 1). This evidence concerns the gene AACS and hepatocellular carcinoma.