2020). On the one hand, some antidepressant drugs could relieve the depression manifestations by enhancing hippocampal autophagy through the brain-derived neurotrophic factor (BDNF)–tyrosine kinase receptor B (TrkB) pathway (Liu et al. 2020). On the other hand, the antidepressant effect via upregulation of the BDNF–TrkB pathway attenuated autophagy in the hippocampus (Song et al. 2017). This evidence concerns the gene NTRK2 and major depressive disorder.