BDNF and major depressive disorder: 2020). On the one hand, some antidepressant drugs could relieve the depression manifestations by enhancing hippocampal autophagy through the brain-derived neurotrophic factor (BDNF)–tyrosine kinase receptor B (TrkB) pathway (Liu et al. 2020). On the other hand, the antidepressant effect via upregulation of the BDNF–TrkB pathway attenuated autophagy in the hippocampus (Song et al. 2017).