In multivariate analysis, presence of severe AP (OR: 26.76, 95% CI: 3.16-226.37, P < .003), acute necrotic collection and walled-off necrosis (OR: 3.45, 95% CI: 1.01-11.78, P < .048), major polypharmacy (OR: 1.18 95% CI: 0.42-3.66, P < .043), creatinine >2.4 mg/dL (OR: 2.15, 95% CI: 0.92-20.6, P < .031), and C-reactive protein (CRP) >40 (OR: 1.1, 95% CI: 1-2.79, P < .001) were found as independent factors affecting mortality in group III (Table 5). This evidence concerns the gene CRP and alkaline phosphatase measurement.