Transgenic HD sheep do not exhibit many of the overt behavioral phenotypes seen in human HD patients, aside from circadian disturbances, but do show signatures of mHTT-mediated pathology including the development of cortical mHTT-positive inclusions, evidence of increased brain urea, as well as loss of cannabinoid receptor 1 (CB1) and dopamine- and cyclic AMP-regulated phosphoprotein (DARPP-32) in the globus pallidus (Jacobsen et al., 2010; Reid et al., 2013; Handley et al., 2016; Handley et al., 2017). The gene discussed is PPP1R1B; the disease is Huntington disease.