TP53 and cancer: SCFAs have the ability to inhibit tumor growth by reversing epigenetic changes by acting as histone deacetylase (HDAC) inhibitors; they can promote cancer cell death by regulating miRNA; by stimulating the expression of cell cycle‐regulated genes p53 and p21, reducing the Expression of anti‐apoptotic Bcl‐2 protein, as well as increased expression of pro‐apoptotic Bax protein, increases apoptosis in some adenomas and cancer cells.26, 27