Moreover, in HCC, COMMD10 suppresses TNF‐mediated ubiquitination of IκBα and p65 nuclear translocation via the coupling of the COMMD10‐N terminal to the Rel homology domain of p65, along with increase of NF‐κB inactivity and production of cleaved caspase 9/3, thereby hampering the progression of HCC.26 Here, COMMD10 is linked to hepatocellular carcinoma.