NF‐κB is a classic inflammatory pathway protein that facilitates human tumors, COMMD1 can mediate the degradation of NF‐κB through ubiquitination to regulate NF‐κB expression negatively, and low expression of COMMD1 can boost cell proliferation and aggressive viability in prostate cancer,40 lung cancer,41 and neuroblastoma.42 Here, COMMD1 is linked to Familial prostate cancer.