The cBioPortal database was used to explore the genetic alterations of COMMD2 in different tumors, as illustrated in Figure 6I, which ranked first in terms of the proportion of all genetic alteration types, particularly in esophageal squamous cell carcinoma, NSCLC, cervical squamous cell carcinoma, and HNSC. The gene discussed is COMMD2; the disease is esophageal squamous cell carcinoma.