ANGPT1 and heart failure: We believe that this counteracted the subsequently increased activity of the RAAS, SNS, and endothelin systems and attenuated their long-term deleterious influence, in agreement with the proposed role of ANG 1–7, particularly under conditions of elevated kidney ANG II levels [77,78], and with the recent evidence that the elevated ANG 1–7/ANG II ratio predicts a beneficial outcome of heart failure [79].