The researchers proposed acupuncture attenuates cognitive impairment associated with inflammation through inhibition of the miR-93-mediated TLR4/MyD88/NF-κB signaling pathway in experimental VD, and acupuncture may be an underlying TLR4 inhibitor for the treatment of VD (Bu et al., 2022). The gene discussed is NFKB1; the disease is Cognitive impairment.